Expression of protein MUC1 and MUC2 in intraductal papillary mucinous neoplasms and its significance / 第二军医大学学报

ABSTRACT

Objective: To investigate the expression of protein MUC1 and MUC2 in intraductal papillary mucinous neoplasms (IPMNs) and its significance. Methods: Immunohistochemical method (En Vision) was used to analyze the expression of protein MUC1 and MUC2 in 18 IPMNs and 9 pancreatic ductal adenocarcinomas. Results: Expression of protein MUC1 was detected in 4 of the 18 (22%) IPMNs (including 1 with pancreatic intraductal papillary-mucinous carcinoma) and all the 9 (100%) the pancreatic ductal adenocarcinomas, with the latter significantly higher than the former(P<0.01). Expression of protein MUC2 was detected in 17 of the 18 (94.4%) IPMNs and in 1 of the 9 (11.1%) pancreatic ductal adenocarcinomas, with the former significantly higher than the latter(P< 0.01). The expression levels of MUC2 were significantly different in IPMNs of different types (IPMA, IPMB, and IPMC, P<0.05). Conclusion: IPMNs have high expression of MUC2 and the expression is associated with the pathological types of IPMN. MUC1 expression may serve as a marker of malignant IPMNs and is worth further studying.