Comparison of electret and chemical enhancers in enhancing transdermal delivery of meloxicam / 第二军医大学学报

ABSTRACT

Objective: To compare the effects of electret and chemical enhancers in enhancing the transdermal delivery of meloxicam. Methods: The study was divided into 4 groups, including meloxicam patch group (control), chemical enhancer + meloxicam patch group, electret meloxicam patch, and electret + chemical enhancer + meloxicam patch group. The in vitro skin permeation of meloxicam from patches was examined by using a modified Franz diffusion cell. Ultraviolet spectrophotometry (362 nm) was used to analyze the drug concentration in the receptor. The 10 h-cumulated permeation amount of meloxicam from patchs was calculated in 3 experimental groups and were compared with that the control group. The enhancing abilities of electret and chemical enhancers were compared and the synergistic effect of them was assessed. Results: (1) 1%, 3% and 5% azones showed 1.20, 1.33, and 1.26 fold-increases in the 10 h-cumulated permeation of meloxiam respectively as compared with control group(P<0.05). (2) Most of the chemical enhancers used in this study(1%, 3% and 5% azones, 10% ethyl oleate, 1% menthnol,and 30% sulphoxiade),except for 20% propylene glycol,had enhancing effect on transdermal delivery of melocicam. Ethyl oleate(10%) was proven to be the most potent enhancer,showing a 1.86-fold cumulated permeation that of the control group(P<0.05); (3) Electret was more potent than the chemical enhancers in promoting meloxicam transdermal delivery, showing a 2.16-fold cumulated permeation that of control group (P<0.05); (4) Electret improved the enhancing effect of chemical enhancers in this study. The cumulated permeation of meloxicam in electret + chemical enhancer + meloxicam patch group was 1.14-2.82 folds that of the chemical enhancer + meloxicam patch group(P<0.05). Conclusion: Electret has a good promoting effect for transdermal drug delivery and can be used as a novel enhancer in transdermal delivery of drugs.