Physicochemical properties of calcium phosphate cement incorporated with anti-tumor drugs / 第二军医大学学报

ABSTRACT

Objective: To study the influence of anti-tumor drug incorporation on the physicochemical properties of calcium phosphate cement(CPC). Methods: Methotrexate (MTX), epirubicin (EPI), hydroxy camptothecin (OH-CPT), and arsenic trioxide (As2O3) were incorporated, each in a proportion of 2%, 5%, and 8%, into the powder-phase CPC. Untreated CPC was taken as control. The setting time, compression strength, and the microstructure of the resultant products were evaluated and tested. Results: Compared with control group, the setting time was significantly prolonged when 2% EPI was incorporated into CPC (P<0.05), and the maximum compression strength was significantly decreased when 5% OH-CPT and 8% MTX, EPI were incorporated into CPC (P<0.05). Electron microscope showed no significant change in the crystal structure after incorporation of the drugs. Conclusion: CPC is an ideal anti-tumor drug delivery material. The changes of physicochemical properties of CPC must be considered when anti-tumor drugs are incorporated into CPC for clinical application.