Synthesis of novel 1, 2, 3, 4-tetrahydroisoquinolines and study of their anti-fungal activities / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 1299-1303, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-841241
ABSTRACT
Objective:
To design and synthesize novel tetrahydroisoquinolines with anti-fungal activities.Methods:
3,4-dimethoxyphenylethylamine was taken as the template and the title compounds were synthesized through Pictet-Spengler reaction, neutralization reaction, substitution, hydrolysis, and acylation.Results:
Twelve title compounds were obtained and all of them were firstly reported. Besides, all the target compounds had anti-fungal activities. The anti-fungal activities of compounds 6-8 and 10-12 were similar to or stronger than that of fluconazole's.Conclusion:
Title compounds obtained in this study belong to a new type of anti-fungal agent, which deserves further study.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Academic Journal of Second Military Medical University
Año:
2010
Tipo del documento:
Artículo
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