Low Dose Megestrol Acetate for Maintenance Hemodialysis Patients / 대한신장학회지
Korean Journal of Nephrology
;
: 302-309, 2009.
Artículo
en Coreano
| WPRIM
| ID: wpr-84135
ABSTRACT
PURPOSE:
Maintenance hemodialysis (HD) patients have a high prevalence of malnutrition and inflammation. Megestrol acetate (MA) has been shown to increase appetite in cancer patients but the usual dose of MA (400-800 mg/day) was associated with serious side effects in HD patients. We evaluated the changes in nutritional and inflammatory parameters after low dose of MA treatment in malnourished HD patientsMETHODS:
Inclusion criteria were maintenance HD patients who showed serum albumin <3.5 g/dL or <4.0 g/dL with anorexia. Serum chemical parameters, cytokines, Subjective Global Assessment, dry weight, Kt/V, nPCR, SF36 quality of life, fat free mass (FFM), and body fat mass (BFM) were measured. Patients were instructed to take 5 mL (200 mg) of MA solution once a day.RESULTS:
Fourteen patients (seven male, age 52+/-10 years, mean HD duration 48+/-59 months) were included. One patient died of pneumonia. Seven patients dropped out because they refused to take the drug after one to three months of treatment; two of them complained of thirst, three of them ate too much, and two had both. Six patients (four male and two female) have completed six months of study. Serum albumin (3.1+/-0.5 to 3.6+/-0.4 g/dL), TIBC (184.2+/-27.9 to 205.0+/-25.8 microgram/ dL), BFM (11.9+/-5.7 to 16.6+/-7.4 kg), protein intake (57.0+/-32.5 to 68.7+/-39.2 g/day), and energy intake (1,521+/-690 to 1,724+/-879) were increased. Serum CRP and IL-6 decreased without statistical significance. No significant adverse effects were observed in all patients who had completed study.CONCLUSION:
Low dose MA can improve the nutritional status, inflammation, and anorexia in maintenance HD patients.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Apetito
/
Neumonía
/
Calidad de Vida
/
Sed
/
Ingestión de Energía
/
Albúmina Sérica
/
Anorexia
/
Tejido Adiposo
/
Estado Nutricional
/
Prevalencia
Tipo de estudio:
Estudio de prevalencia
Límite:
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Nephrology
Año:
2009
Tipo del documento:
Artículo
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