Renal Recovery from Severe Acute Kidney Injury Requiring Renal Replacement Therapy / 대한신장학회지
Korean Journal of Nephrology
;
: 295-301, 2009.
Artículo
en Coreano
| WPRIM
| ID: wpr-84136
ABSTRACT
PURPOSE:
Acute tubular necrosis (ATN) is a serious complication in critically ill patients. This study investigated the renal outcome of severe ATN requiring RRT and prognostic factors for renal recovery.METHODS:
Between January 2000 and May 2008, surviving patients with presumed ATN requiring dialysis were analyzed retrospectively. Patients with pre-existing chronic kidney disease and other causes of ARF rather than ATN were excluded. Primary outcomes were complete renal recovery (CR) and dialysis withdrawal. CR was defined as a return to basal serum creatinine level or creatinine <1.5 mg/dL (male) or <1.3 mg/dL (female) without dialysis.RESULTS:
Of one hundred twenty two patients, 79 (65%) patients were male. The mean age was 54+/-16 years and 87 patients (71%) received continuous renal replacement therapy. 55% had ischemic ATN, 29% had septic ATN, and 16% had nephrotoxic ATN. Mean duration of dialysis was 12 (6-29) days. Dialysis withdrawal rate at 30 days and at 60 days after initiation of dialysis were 51% and 77 %, respectively. CR at 60 days after initiation was 50%. Multivariate analysis revealed that older age (per year, Hazard ratio (HR)=0.981, 95% Confidence interval (CI) 0.963 to 0.999), ischemic ATN (vs. toxic ATN, HR=0.481, 95% CI 0.238 to 0.974),and longer duration of oliguria (per day, HR=0.979, 95 % CI 0.962 to 0.996) were independent prognostic factors of renal recovery.CONCLUSION:
Young age and short duration of oliguria were favorable factors for renal recovery from ATN requiring dialysis. The cause of ATN might be also an independent prognostic factor.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Oliguria
/
Análisis Multivariante
/
Estudios Retrospectivos
/
Enfermedad Crítica
/
Terapia de Reemplazo Renal
/
Creatinina
/
Diálisis
/
Insuficiencia Renal Crónica
/
Lesión Renal Aguda
/
Necrosis de la Corteza Renal
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Nephrology
Año:
2009
Tipo del documento:
Artículo
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