Expression of Fas ligand and T cell intracellular antigen-1 during acute after renal transplantation / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 409-412, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-841449
ABSTRACT
Objective:
To study the intrarenal expression of Fas ligand (FasL) and T cell intracellular antigen-1 (TIA-1) protein during acute rejection after renal transplantation.Methods:
Immunohistochemical technique was used to detect FasL and TIA-1 expression in 32 transplanted renal samples,2 living donor kidneys and 8 adjacent samples of renal cancer (including 14 acute rejection samples, 15 chronic and 13 non-rejection ones according to Banff criteria).Results:
The positive FasL staining was observed mainly in cytoplama of renal tubule epithelia, and the positive rate was significantly higher in acute rejection samples than in others(P<0.01). TIA-1 was found in both tubular epithelial cells and interstitial infiltrating lymphocytes, occasionaly in small arterial endothelial cells. The positive staining rate of TIA-1 acute rejection samples was also higher than those of other samples(P<0.05). The expression of FasL and TIA-1 in acute rejection samples was positively correlated with the severity of tissue damages.Conclusion:
Over expression of FasL and TIA-1 in acute rejection renal allograft tissues may indicate the activation of T cells,and its detection may be helpful for early diagnosis of acute rejection.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio de tamizaje
Idioma:
Chino
Revista:
Academic Journal of Second Military Medical University
Año:
2006
Tipo del documento:
Artículo
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