Trichophyton rubrum: Relationship between susceptibilities to antifungal agents and species specificities / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 136-139, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-841489
ABSTRACT
Objective:
To study the relationship between susceptibilities of Trichophyton rubrum strains to antifungal agents and their species specificities.Methods:
The susceptibilities of Trichophyton rubrum strains to itraconazole, ketoconazole, fluconazole, terbinafine, naftifine, 5-flucytosine and amphotericin B were evaluated using a modified microdilution method. The relationship between susceptibilities and genotypes and phenotypes of Trichophyton rubrum strains with different origins was analyzed by random amplified polymorphic DNA (RAPD).Results:
The Trichophyton rubrum strains showed narrow minimum inhibitory concentration (MIC) ranges to terbinafine (0.016-0.032 μg/ml), naftifine (0.032-0.063 μg/ml) and itraconazole (0.25-1 μg/ml), whereas they showed broader MIC ranges to ketoconzole (0.25-2 μg/ml) and fluconazole (1-32 μg/ml). MICs of Trichophyton rubrum strains to terbinafine (M0 = 0.032 μg/ml) and naftifine (M0 = 0.032 μg/ml) were the lowest among 7 antifungal agents. Wilcoxon test (Kruskal-Wallis test) suggested that there was no significant relationship of MICs to terbinafine, naftifine, itraconazole and amphotericin B with the genotypes, phenotypes and origins of the Trichophyton rubrum strains.Conclusion:
The antifungal susceptibility of Trichophyton rubrum strains may not be related to their genotypes, phenotypes or from which part of the body they are isolated.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Academic Journal of Second Military Medical University
Año:
2006
Tipo del documento:
Artículo
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