Predtive values of thromboelastograph, mean platelet volume/platelet count ratio and fibrinogen level in recurrent spontaneous abortion / 吉林大学学报(医学版)

ABSTRACT

Objective: To detect the thromboelastrography (TEG) parameters, mean platelet volume (MPV)/platelet count (PC) ratio and plasma fibrinogen (FIB) level in the patients with recurrent spontaneous abortionin (RIA) in non-pregnant state, and to evaluate their predictive values in the disease. Methods: A total of 206 patients with RIA history were selected as observation group and 92 healthy women who underwent prenatal examination during the same period were selected as control group. The TEG parameters, MPV, PC and FIB levels of the subjects in two groups were measured, and the predictive values of relevant indicators in RIA were evaluated. Results: Compared with control group, the setting time (K value) of TEG parameters of the patients in observation group was decreased (P0.05). The areas under receiver operating characteristic (AUC) curve of MA value, MPV/PC ratio and FIB level were 0.694, 0.673 and 0.735, respectively. The results showed that the three paramerters had good clinical predictive values in RIA. Conclusion: The K value, a angle, MA value, MPV/PC ratio and FIB level in the RSA patients have changed in the non-pregnant state, which is of great value in the early prediction of RSA.