Expressions of TGF-β1 and PLGF in tissue of patients with different types of gestational trophoblastic diseases and their significances / 吉林大学学报(医学版)

ABSTRACT

Objective; To detect the expressions of transforming growth factor-β1 (TGF-β1) and placental growth factor (PLGF) expressions in the tissue of the patients with different types of gestational trophoblastic diseases, and to clarfy the significances of their expressions in different types of gestational trophoblastic diseases. Methods: A total of 40 cases of hydatidiform mole tissue (hydatidiform mole group) and 26 cases of gestational trophoblastic tumour tissue (GTN group, including 22 cases of invasive hydatidiform mole and 4 cases of choriocarcinoma), and 40 cases of normal early pregnancy villi (normal control group) were collected. Immunohistochemical method was used to detect the positive expression rates of TGF-β1 and PLGF, the differences of TGF-β1 and PLGF expressions between normal group, hydatidiform mole group and GTN group were analyzed, and the associations between them and the clinical high risk factors (age>40 years old, the uterine volume> gestational age, and thecalutein ovarian cyst diameter>6 cm) were analyzed. Results: The positive expression rates of TGF-β1 in hydatidiform mole group (62. 5%) and GTN group (30. 8%) were lower than that in normal group (87. 5%) (P40 years old, the uterine volume>the gestational age, and the ovarian luteinized cyst diameter>6 cm were significantly decreased (P<0.05) and the positive expression rates of PLGF were significantly increased (P<0. 05) compared with normal control group. The positive expression rate of TGF-β1 of the patients in GTN group with the high risk factors was significantly decreased compared with those without the high risk factors (P<0. 05) and the positive expression rate of PLGF was significantly increased (P<0. 05). In hydatidiform mole group and GTN group, there were moderately negative correlations between the positive expression rates of TGF-β1 and PLGF (r= -0. 585, P<0. 05; r= -0. 479, P< 0. 05). Conclusion: The expression levels of TGF-β1 in hydatidiform mole and gestational trophoblastic tumor are gradually decreased, and the expression levels of PLGF are gradually increased, which may be related to the different types and prognosis of gestational trophoblastic diseases.