Formulation optimization, in situ intestinal absorption and permeability of psoralen and isopsoralen / 中草药·英文版
Chinese Herbal Medicines
;
(4): 337-343, 2019.
Artículo
en Chino
| WPRIM
| ID: wpr-842067
ABSTRACT
Objective:
To optimize a self-emulsifying drug delivery system (SEDDS) formulation for psoralen and isopsoralen (PSO and IPSO) isolated from Psoraleae Fructus.Methods:
A D-optimal design was used to investigate the influence of oil percentage, surfactant percentage and cosurfactant percentage on several properties of SEDDS including particle size, polydispersity, equilibrium solubility, in situ intestine absorption rate and intestinal permeability. Furthermore, the desirability function approach was applied to obtain the optimal formulation for the system.Results:
The oil percentage, surfactant percentage and cosurfactant percentage were optimized to be 53.6%, 35.7% and 10.7%, respectively, which means the model is available.Conclusions:
The D-optimal design is valuable to optimize the SEDDS formulation and understand formulation compositions’ functions on SEDDS properties.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Herbal Medicines
Año:
2019
Tipo del documento:
Artículo
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