Antidiabetic and Anti-oxidative Effects of Honokiol on Diabetic Rats Induced by High-fat Diet and Streptozotocin / 中草药·英文版
Chinese Herbal Medicines
;
(4): 42-46, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-842316
ABSTRACT
Objective:
To study the antidiabetic and anti-oxidative effects of honokiol (Hon) in Magnolia officinalis and its underlying molecular mechanism in diabetic rats induced by high-fat diet (HFD) and streptozotocin (STZ).Methods:
After ig administration with Hon [25, 50, and 100 mg/(kg·d)] to diabetic rats for consecutive 10 weeks, the levels of blood glucose (BG), oral glucose tolerance (OGT), blood lipids including total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), and low density lipoprotein-cholesterol (LDL-C), hepatic oxidative stress including the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), methane dicarboxylic aldehyde (MDA), and cytochrome P4502E1 (CYP2E1) in diabetic rats were measured.Results:
Compared to the diabetic control rats, ig administration of Hon resulted in significant decrease in BG, TC, TG, and LDL-C levels in serum, as well as hepatic CYP2E1 activity and MDA content in diabetic rats, whereas the level of OGT and activities of hepatic CAT, SOD, and GSH-Px in diabetic rats were significantly increased.Conclusion:
Hon could alleviate hyperglycemia, hyperlipemia, hepatic oxidative damage, and insulin resistance in diabetic rats by inhibiting hepatic CYP2E1 activity. © 2014 Tianjin Press of Chinese Herbal Medicines.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Herbal Medicines
Año:
2015
Tipo del documento:
Artículo
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