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The Effect of Subthalamic Nucleus Stimulation in Patients with Advanced Idiopathic Parkinson's Disease
Journal of the Korean Neurological Association ; : 234-242, 2002.
Artículo en Coreano | WPRIM | ID: wpr-84273
ABSTRACT

BACKGROUND:

To determine the efficacy and safety of subthalamic nucleus (STN) stimulation in patients with advanced Parkinson's disease (PD).

METHODS:

In 5 patients with PD, we evaluated the effect of bilateral STN stimula-tion. Using the Unified PD Rating Scale (UPDRS), Clinical Dyskinesia Rating Scale, Activities of Daily Living(ADL) Score and patient's diary, we evaluated the patients before and at one, three and 12 months after surgery. We examined the patients while they were drug "off" and "on".

RESULTS:

While patients were "off", stimulation induced a signifi-cant reduction in the UPDRS part III score by 46% at 12 months after the operation, compared to the baseline state. During drug "on" state, levodopa-induced dyskinesias were reduced by 88% at 12 months after the operation. Off-peri-od dystonia was reduced by 45% at 12 months after the operation. ADL scores also improved after the stimulation. Patients' diaries showed significant reduction in the "off" period while awake (73% reduction at 12 months). The daily dose of levodopa was reduced by 56% at 12 months after the operation. There was no significant complication related to the surgical procedure or electrical stimulation.

CONCLUSIONS:

We conclude that STN stimulation is an effective and safe treatment strategy for the patients with advanced PD.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Enfermedad de Parkinson / Actividades Cotidianas / Levodopa / Núcleo Subtalámico / Discinesias / Distonía / Estimulación Eléctrica Límite: Humanos Idioma: Coreano Revista: Journal of the Korean Neurological Association Año: 2002 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Enfermedad de Parkinson / Actividades Cotidianas / Levodopa / Núcleo Subtalámico / Discinesias / Distonía / Estimulación Eléctrica Límite: Humanos Idioma: Coreano Revista: Journal of the Korean Neurological Association Año: 2002 Tipo del documento: Artículo