Global levels of lysine crotonylation in prostate cancer and its correlation with clinical stages and pathologic grades / 上海交通大学学报（医学版）

ABSTRACT

Objective • To study whether lysine crotonylation can be used as a candidate biomarker for prostate cancer diagnosis, and its correlation with clinical stages and pathologic grades. Methods • Seventy-three cases of tumor and 7 normal prostate tissues were included in the study. The global levels of lysine crotonylation and histone H4 acetylation were detected in each sample by immunohistochemistry. Statistical comparison and correlation analysis were performed. Results • Compared with normal prostate tissue, the global level of lysine crotonylation was significantly reduced in prostate cancer tissue (P=0.001), while histone H4 acetylation levels were close to each other in two groups (P=0.704). No statistical difference in the levels of lysine crotonylation or histone H4 acetylation were found in different clinical stages and pathologic grades (P>0.05). There was no correlation between histone H4 acetylation and clinical stages or pathologic grades of prostate cancer. There was a positive correlation between lysine crotonylation and the grading of prostate cancer (r=0.493, P=0.000). Conclusion • Compared to histone H4 acetylation, lysine crotonylation is a better candidate biomarker to diagnose prostate cancer.