Correlation between vitamin D concentration and gestational anemia / 西安交通大学学报(医学版)

ABSTRACT

Objective: To investigate the correlation between vitamin D concentration and gestational anemia. Methods: For this study we recruited 4532 pregnant women (≤12 pregnant weeks) who received the pregnancy care in obstetrics outpatient in The First Affiliated Hospital of Xi'an Jiaotong University from December 2015 to February 2016; those with anemia were excluded. Baseline survey and follow-up till childbirth were conducted among them. We carried out a nested case-control study with a 12 ratio. Three hundred and eighty-eight pregnant women with anemia detected in this study served as case group, while 766 pregnant women without anemia randomly selected and matched by age (±2 years), gestational habitual residence served as control group. And t test, χ2 test, Mann-Whitney U test and logistic regression analysis were conducted to identify the association between vitamin D concentration and gestational anemia. Results: Among the 383 pregnant women with anemia, 71.5% of them had serum 25(OH)D concentration <50.0 nmol/L, while 60.1% in the control group. The difference of vitamin D level in the two groups was significant (P<0.05). Logistic regression analysis indicated that women with 25(OH)D concentration <30 nmol/L and 30-50 nmol/L had an increased risk of gestational anemia when compared with women with the concentration of 50-75 nmol/L. After adjustment for confounders, for women with concentration <50.0 nmol/L, they had an 74% (OR1.74, 95% CI 1.27-2.38) increase in anemia risk when compared with those with the concentration of 50-75 nmol/L. Conclusion: Vitamin D deficiency is significantly associated with gestational anemia, suggesting that we should pay attention to monitoring women's vitamin D concentration.