Treatment Update on Portal Hypertension and Complications / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 144-154, 2010.
Artículo
en Coreano
| WPRIM
| ID: wpr-84437
ABSTRACT
Current understanding of the pathophysiology of portal hypertension has resulted in therapeutic approaches aimed at correcting the increased splanchnic blood flow and some of which have been already used in clinical practice. Recently new perspectives opened and erstwhile paradigm has been changed to focus on increased resistance to portal blood flow and the formation of portosystemic collateralization. Several studies revealed the clear-cut mechanisms of hepatic endothelial dysfunction and abnormal angiogenesis contributing to the development of portal hypertension. Thus the modulations of hyperdynamic circulation or angiogenesis seem to be valuable therapeutic targets. In the current review update, we discuss the multidisciplinary management of modulating hepatic vascular resistance and abnormal angiogenesis associated with portal hypertension. However, these new pharmacological approaches are still under investigation and widescale clinical application are needed to develop effective strategies.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Resistencia Vascular
/
Vasoconstrictores
/
Trasplante de Médula Ósea
/
Inhibidores de la Ciclooxigenasa
/
Antagonistas Adrenérgicos beta
/
Inhibidores de Hidroximetilglutaril-CoA Reductasas
/
Hipertensión Portal
/
Neovascularización Patológica
/
Óxido Nítrico
Límite:
Humanos
Idioma:
Coreano
Revista:
The Korean Journal of Gastroenterology
Año:
2010
Tipo del documento:
Artículo
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