The experimental observation on the repairing spinal cord injury by olfactory ensheathing cells allograft of different sources / 西安交通大学学报·英文版

ABSTRACT

Objective: To observe the repaired effect of distinct source olfactory ensheathing cells (OECs) on spinal cord injury (SCI) rats. Methods: These OECs were dissociated from olfactory bulb and olfactory mucosa of SD rats and transplanted to the injuried region of spinal cord injury rats. The function of nerve, motor evoked potential of hind legs and the histopathlogical diversities of injuried spinal cord were observed. Results: The OECs grafts into the SCI area could survive longer time. The BBB scale, incubation stage of EP and histopathologic manifestations showed that the group with transplanted OECs regained more improvement in hindlimb than the control group. Conclusion: The OECs of two sources have the same ability to regain and improve the axonal function which can promote axons regeneration of SCI.