Research progress on the correlation between TLR4-MyD88-NF-κB signalling pathways and the hepatic inflammation-fibrosis-cancer axis / 国际药学研究杂志

ABSTRACT

As a critical pathway in the reaction of hepatic disease, Toll-like receptor 4(TLR4)-myeloid differentiation factor 88(MyD88)-nuclear transcription factor(NF-κB)signalling pathway, which widely exists in various tissues and cells, is one of the most important signalling pathways that mediate the expression of inflammatory factor between the intracellular and intercellular. Study found that TLR4-MyD88-NF-κB signalling pathway plays an important role in the regulation of liver immune abnormalities, inflammatory response triggered by the liver damage, activation of hepatic stellate cells and liver fibrosis deterioration and the development of cancer of the liver. The signalling pathway may be an important regulatory point in the dynamic changes of the”hepatic inflammationfibrosis-cancer axis”(IFC axis)and liver cancer metastasis. In this paper, we review the recent advances in the pathological mechanism of TLR4-MyD88-NF-κB signalling pathway participating in IFC axis disease, so as to provide reference for related research in the future.