Implication of canonical transient receptor potential in cardiovascular disease / 国际药学研究杂志

ABSTRACT

The canonical transient receptor potential(TRPC) regulating non-voltage-gated cation entry in plasma-membrane is widely expressed in cardiovascular system. Cytosolic Ca2+ takes charge of multifunctional biogenic activities and its stabilization is critical for physiological function. Almost all TRPC channels are non-selectively permeable for Ca2+. Overexpression or transgenation of TRPC leading to the change of Ca2+ may contribute to fundamental malfunctions and engage in the physiological and pathophysiological processes of some diseases. Evidence suggests that regulation of TRPC channels plays important roles in the development of hypertension, pulmonary arterial hypertension, cardiac hypertrophy, atherosclerosis, and arrhythmia. This review gives an overview of the functional properties of mammalian TRPC channels, describes their roles in cardiovascular diseases and discusses their potential as drug targets for therapeutic intervention.