Multiple-target agents in the therapy of Alzheimer’s disease: Research advances / 国际药学研究杂志
Journal of International Pharmaceutical Research
; (6): 205-215, 2016.
Article
en Zh
| WPRIM
| ID: wpr-845570
Biblioteca responsable:
WPRO
ABSTRACT
Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder. The available therapy is mainly Acetyl cholinesterase (AChE) inhibitors and N-methyl-D-aspartate (NMDA) antagonist, which are single-target AD drugs. They are limited symptomatic treatment and their efficacy remains unsatisfactory. Due to the complexity and multifactorial etiology of AD, the multi-target-directed ligand approach is a hopeful way of searching new anti-AD drugs. Here we review the advancement of multitarget AD drugs in recent years: single compound with more than one target, multicomponent drug and drug combination.
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WPRIM
Idioma:
Zh
Revista:
Journal of International Pharmaceutical Research
Año:
2016
Tipo del documento:
Article