Recent progress of hypoxia inducible factor-prolyl hydroxylase domain containing enzymes inhibitors / 国际药学研究杂志

ABSTRACT

Hypoxia inducible factor (HIF) is a transcription factor widely existing in mammalian and human cells. Prolyl hydroxylase domain-containing enzymes (PHD) is the rate-limiting enzyme of HIF degradation which can hydroxylize proline residues of HIF. Therefore, HIF-PHD inhibitors (PHI) may participate in regulating the expression of gene mediated by HIF, and play important biological roles, for example, pharmacological stabilization of HIF protein with PHD inhibitors can increase the expression of erythropoietin. In this review, PHI are mainly classified according to their mechanism, and the potential indications and the latest clinical research progress of a few small molecular PHI are surveyed.