Insulin signaling pathway and glucose metabolism in Alzheimer’s diseases / 国际药学研究杂志

ABSTRACT

Alzheimer’s disease AD is a degenerative metabolic disease, whose exact pathological mechanism still remains unknown. Currently, studies have found that patients in AD accompany with insulin signaling pathway impairment and cerebral glucose metabolism dysfunction. As insulin signaling pathway and cerebral glucose metabolism homeostasis play a key role in AD, some researches consider AD as“type III diabetes”. This review aims to discuss the alteration of cerebral insulin signaling pathway and glucose metabolism in AD, as well as their relationship with AD. We will also elaborate the advance in anti-AD drugs based on cerebral insulin signaling pathway.