Contribution of luteinizing hormone to Alzheimer’s disease / 国际药学研究杂志

ABSTRACT

Luteinizing hormone(LH)is a gonadotropin of hypothalamic-pituitary-gonadal axis(HPG), secreted by the anterior pituitary. The secretion of LH is directly controlled by the release of gonadotropin releasing hormone(GnRH), acts at the ovaries and testes to stimulate the production of gonadal hormones. Aging leads to increases in LH, and higher serum levels of LH has been observed in Alzheimer’s disease(AD)patients when compared to age-matched controls. Evidences from basic research and epidemiological investigation support the critical role of elevated LH in pathogenic process of AD and deteriorating cognitive decline. Here we summarize the recent discoveries containing human AD epidemiological evidence for LH, cognitive impairments resulting from LH activity, LH in AD pathology and LH receptor signaling mechanisms.