Pharmacological properties of 7-ethyl-10-hydroxy-camptothecin derivatives: Research advances / 国际药学研究杂志
Journal of International Pharmaceutical Research
;
(6): 310-315, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-845687
ABSTRACT
7-Ethyl-10-hydroxycamptothecin (SN-38) is a prominent anticancer agent, but it is insoluble in water and the most pharmaceutically acceptable solvents, the lactone ring of SN-38 shows reversible pH-dependent hydrolysis and forms to the open lactone in alkaline condition. All of these factors limit its application in clinic, and a variety of chemical modification studies have been reported to improve the efficient use of SN-38 by improving its solubility in water and pharmaceutical solvents, stabilizing the lactone form, and altering the pharmacological properties. This paper reviews the pharmacological properties of commercial SN-38 derivatives in clinical trials or preclinical studies and their research progress.
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Journal of International Pharmaceutical Research
Año:
2015
Tipo del documento:
Artículo
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