Regulatory B cells: Research advances / 国际药学研究杂志

ABSTRACT

B cells notionly can regulate the immune responses by producing antibody, presenting antigens to target immune cells, but also have the function of immune suppression. A small quantity of regulatory B (Breg) cells in vivo is capable of performing regulatory functions by producing of inhibitory cytokines,such as interleukin -10, or by direct interaction with other immune cells. In vivo, Breg can maintain immune tolerance and inhibit excessive inflammatory responses efficiently. Clinical studies indicate that Breg are associated with some autoimmune diseases, cancers, infections, and transplantation tolerance. The review focuses on molecules associated with the differentiation and function of the Breg. And also, we discuss the mechanisms and the relations of Breg to clinical diseases.