ATP-binding cassette superfamily G member 2 and uric acid metabolism: Research advances / 国际药学研究杂志

ABSTRACT

TP-binding cassette superrfamily G member 2(ABCG2), a transporter protein localizing in cell membrane and expressing in renal tubular epithelial cell brush border side, has the function of transport uric acid. In recent years, single nucleotide polymorphism (SNP) analysis has confirmed that ABCG2 is one of the most important uric acid transporters, whose dysfunction would hinder the kidney and intestinal excretion of uric acid, then increase serum uric acid and causes gout. The review summarizes the relationship between ABCG2 transporter protein and uric acid metabolism, and the SNP affecting on uric acid metabolism.