Anti-HIV macrophage-targeted drug delivery systems: Research advances / 国际药学研究杂志

ABSTRACT

Macrophages are the reservoir of human immunodeficiency virus (HIV). HIV hidden in the macrophages is replicated under appropriate conditions, leading to recurrence of AIDS. Macrophages are a new infection resource of HIV. Biomembrane penetration of current anti-HIV drugs is poor and the in vivo half life is short, resulting in high dose and frequent administration. Their distribution in macrophages is too liitle to eradicate the hidden HIV. Therefore, the development of anti-HIV macrophage-targeted delivery systems is very important. The review summarizes the nanoparticulate delivery systems of anti-HIV agents and their macrophage-targeted effects, involving nanoparticles, liposomes, nanosuspensions, self-assembled drug delivery systems, nanogels and nanocapsules, in order to provide a new strategy for the treatment of AIDS.