Pharmacological feature of buprenorphine: Research advances / 国际药学研究杂志

ABSTRACT

Buprenorphine is a semisynthetic opioid derived from thebaine. It has been shown to nteract in vivo and in vitro with multiple opioid receptors with slow receptor binding kinetics. It can act as an agonist and/or antagonist when interacting with different classes of opioid receptors, which contributes to the distinctive pharmacological feature of buprenorphine. This review summarizes the recent research data on the pharmacology of buprenorphine, aiming to accurately understand the efficacy and safety of its clinical use.