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A new fumagillin compound from marine-derived Aspergillus fumigatus MDCW-15 / 中草药
Chinese Traditional and Herbal Drugs ; (24): 6137-6141, 2020.
Artículo en Chino | WPRIM | ID: wpr-845974
ABSTRACT

Objective:

To study the secondary metabolites of marine-derived Aspergillus fumigatus MDCW-15.

Methods:

The secondary metabolites were isolated and purified by column chromatography over silica gel. And their structures were identified by the spectroscopic analysis of NMR and MS. The antifungal bioactivities were assayed by paper diffusion.

Results:

A new fumagillin compound 1 and a known compound 2 were isolated from the fermentation broth of marine-derived Aspergillus fumigatus MDCW-15. The antifungal bioactivities were assayed by paper diffusion. Compounds 1 and 2 showed antifungal activity against Candida albicans with an equal MIC value of 32.0 μg/mL.

Conclusion:

Compound 1 is a new compound named 2'-cis- fumagiringillin. Compounds 1 and 2 exhibit antifungal activities.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Traditional and Herbal Drugs Año: 2020 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Traditional and Herbal Drugs Año: 2020 Tipo del documento: Artículo