Gender Difference of Insulin Resistance in Obese Children and Adolescents / 대한소아내분비학회지
Journal of Korean Society of Pediatric Endocrinology
;
: 84-89, 2005.
Artículo
en Coreano
| WPRIM
| ID: wpr-84640
ABSTRACT
PURPOSE:
It is known that insulin resistance is important because it may precede the development of Diabetes Mellitus. We evaluated the gender difference of insulin resistance in obese children & adolescents.METHODS:
92 obese children and 187 adolescents (age5-16 y, >95th percentile of the body mass index [BMI] for age and sex) were included in this study. The abdominal fat, abdominal circumference, and intraabdominal fat depth (IAFD), plasma fasting insulin, leptin, adiponectin, lipid profiles and high sensitive-C reactive protein (hs-CRP) were measured, and a two-hour oral glucose tolerance test with insulin measurement were performed.RESULTS:
The plasma total cholesterol, leptin, fasting insulin & HOMA-IR levels of obese females were higher than those of obese males. The sex, waist circumference, IAFD & adiponectin levels were strongly correlated with HOMA-IR by multiple linear regression analysis (P<0.05).CONCLUSION:
Adolescent females may have specific fat distribution and were expressed to have higher leptin and relatively lower adiponectin concentration compared to adolescent males, developing higher insulin resistance, even though having lesser abdominal fat and waist size. Further investigation is required to verify the gender difference of insulin resistance in obese children and adolescents.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plasma
/
Resistencia a la Insulina
/
Índice de Masa Corporal
/
Modelos Lineales
/
Colesterol
/
Ayuno
/
Leptina
/
Diabetes Mellitus
/
Grasa Abdominal
/
Adiponectina
Límite:
Adolescente
/
Niño
/
Femenino
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Journal of Korean Society of Pediatric Endocrinology
Año:
2005
Tipo del documento:
Artículo
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