Research progress on macroporous resin application in enriching and separating alkaloids / 中草药

ABSTRACT

Alkaloids is one of the most extensive natural products and one of the most important effective constituents of Chinese materia medica (CMM), most of which have complex ring structure and the effect of antidiabetics, antitumor, antibacterial, antiviral and so on. Macroporous resin is a kind of high-molecular polymer, which cannot be dissolved in acid, alkali and a variety of organic solvents, with the feature of fast adsorption and mild desorption condition, easy regeneration, and long service cycle, etc. In recent years, macroporous resin has been widely applied to the separation and purification of alkaloids and flavonoids. However, there are so many different kinds and variable quality of macroporous resin in the market, as well as multifarious factors influencing the purification effect, the experimental research has been severely affected. In this paper, the application of macroporous resin on separating and enriching alkaloids in recent years had been studied to summarize the main factors affecting the purification effect. The characteristics as well as the problems of macroporous resin were also analyzed. By studying the pretreatment and regeneration process of macroporous resin and optimizing process parameters, the adsorption and desorption performance can be strengthened and the yield or recovery rate of target alkaloids could be enhanced, promoting the further use of macroporous resin in separating and enriching alkaloids from CMM.