Research progress on alkaloid acetylcholinesterase inhibitors from natural products / 中草药

ABSTRACT

Acetylcholinesterase (AChE) inhibitor is research hotspot for the treatment of Alzheimer’s disease (AD), which can be divided into two categories, chemical synthesis and natural products, according to its sources. Alkaloids are important sources of natural AChE inhibitors. In this paper, the research progress of plant-derived alkaloids with the inhibitory activity of AChE was reviewed from the aspects of structure type, mechanism of action and structure-activity relationship, in order to provide reference for the research and development of AChE inhibitors derived from natural alkaloids.