Neurogenesis and neuroinflammation under exercise: Alteration and regulation / 中国组织工程研究

ABSTRACT

BACKGROUND: Studies have found that exercise can regulate neuroinflammation and adult hippocampal neurogenesis, and improve cognitive function. However, the interaction between exercise and neuroinflammation-induced changes in hippocampal neurogenesis and cognitive function is unclear. OBJECTIVE: To analyze and summarize the mechanism by which neuroinflammation-mediated exercise improves adult hippocampus neurogenesis and cognition. METHOD: Using “exercise; neuroinflammation; neurogenesis; Alzheimer’s disease; aging; depression; cerebral ischemia; traumatic brain injury; cognition” as keywords, we retrieved literature regarding the effects or mechanisms of exercise on neuroinflammation, adult hippocampus neurogenesis and cognition in CNKI and Web of Science, and logically analyzed and summarized the included studies. RESULTS AND CONCLUSION: Neuroinflammation can cause nerve damage, and may lead to cognitive impairment, while exercise can effectively produce anti-inflammatory effects in the brain, and promote adult hippocampal neurogenesis, thereby improving cognitive ability. Exercise cannot only directly increase the expression of neurotrophic factors in the hippocampus and promote hippocampal neurogenesis, but also affect the expression of neurotrophic factors in the hippocampus and the process of neurogenesis through its anti-inflammatory mechanism. However, there is still much work to be done to better understand how the neurogenic and inflammatory environment changes under exercise conditions, and how this altered process can be modulated to promote cognition.