Mechanism of autophagy in osteosarcoma / 中国组织工程研究

ABSTRACT

BACKGROUND: Autophagy may be a tumor-inhibiting factor at the early stage of carcinogenesis, while at late stage, it may support or promote the tumor growth and spread, and may contribute to drug resistance. OBJECTIVE: To review the related literature at home and abroad, summarize the relationship between autophagy and osteosarcoma, and explore the mechanism of autophagy in osteosarcoma and its therapeutic prospect. METHODS: CNKI, Wanfang, VIP and PubMed databases were retrieved with the keywords of “autophagy, chemotherapy, autophagy related factors, osteosarcoma, apoptosis, drug resistance” in Chinese and English, respectively. The articles related to the mechanism of autophagy in bone tumors were included. The literature was screened according to the selection criteria, and the repetitive and the long-standing literature were excluded. Fifty-two articles were included for review and analysis. RESULTS AND CONCLUSION: (1) Autophagy may be an important factor in promoting and preventing cancer, and its effect varies with the occurrence of development of tumor. (2) The full understanding and regulation of autophagy pathway can significantly improve the potential of tumor therapy. (3) Considering the importance of autophagy in tumor biology, research on autophagy-regulated miRNA will help us to better understand malignant tumors and may discover new disease markers and treatment strategies. (4) The above conclusion still needs a lot of scientific research and reasonable experiments to confirm.