Meta-analysis of dental implantation success rate in diabetic patients with 6% < glycated hemoglobin level < 8% / 中国组织工程研究

ABSTRACT

BACKGROUND: When glycated hemoglobin level is < 6%, the efficacy of dental implantation in diabetic patients is not significantly different from that in non-diabetic patients. However, there are few studies on whether the dental implantation success rate in diabetic patients with 6% < glycated hemoglobin level < 8% is decreased. OBJECTIVE: To evaluate the dental implantation success rate in diabetic patients with 6% < glycated hemoglobin level < 8%. METHODS: A computer-based retrieval of PubMed, Cochrane library, Embase, CNKI, and Wanfang databases was conducted for the articles published before December 2018. Retrospective and case-control studies comparing the dental implantation success rate between diabetic patients with 6% < glycated hemoglobin level < 8% and non-diabetic patients were retrieved. Data extraction and quality evaluation were performed by two researchers. Meta-analysis was carried out. OR and 95%C/ values were used to estimate the success rate of dental implantation in diabetic patients with 6% < glycated hemoglobin level < 8%. RESULTS AND CONCLUSION: (1) Twelve studies were included, involving 2 698 patients and 9 414 implants. (2) Meta-analysis results showed that there was no significant difference in dental implantation success rate between non-diabetic patients and diabetic patients with 6% < glycated hemoglobin level < 8% [OR=1.13, 95%C/ (0.82,1.54). (3) These results suggest that there is no significant difference in dental implantation success rate between diabetic patients with 6% < glycated hemoglobin level < 8% and non-diabetic patients.