Regulation of osteosarcoma and stem cell-related signaling pathways / 中国组织工程研究

ABSTRACT

BACKGROUND: Osteosarcoma is the most common primary bone-derived malignancy in children and adolescents. The prognosis of osteosarcoma patients has hardly improved over the past 30 years. It is urgent to develop new strategies and innovative therapies to further improve the survival rate of osteosarcoma patients. OBJECTIVE: To explain the latest advances in molecular mechanisms and signaling networks that contribute to the progression and metastasis of osteosarcoma, and provide a theoretical basis for the treatment of osteosarcoma. METHODS: The “osteosarcoma, signaling pathway, prognosis, metastasis, drug resistance, Notch, Wnt/β-catenin, Hedgehog, PI3K/Akt/mTOR, BMPs” were as keywords to search the articles in the CNKI and PubMed databases published from February 1999 to February 2019. Totally 586 related articles were retrieved. After reading the title and abstract, irrelevant articles were excluded based on exclusion criteria, and finally 40 eligible articles were included for review. RESULTS AND CONCLUSION: Signaling pathways are critical in the regulation of osteosarcoma formation and proliferation. Studies have found that Notch, Wnt/β-catenin, Hedgehog, PI3K/Akt/mTOR and BMP signaling pathways are expressed in osteosarcoma and stem cells, which have an important impact on the occurrence and development of osteosarcoma.