Microrna-214 is involved in the regulation of bone metabolism / 中国组织工程研究

ABSTRACT

BACKGROUND: MicroRNAs (miR) is an important endogenous non-coding small RNA that regulates the expression of genes by regulating the translation of mRNA. In recent years, it has been found that miR-214 plays an important role in related bone metabolic signaling pathways, which can regulate bone resorption and bone formation by targeting related genes. OBJECTIVE: To review the new progress in the regulatory mechanism and possible application of miR-214 in bone metabolism. METHODS: The first author searched PubMed, Web of Science, and Medline with the keywords of “miRNA, miR-214, osteogenesis, osteoblast,” “miR-214, bone remodeling,” and “miR-214, osteoclast, tissue engineering” respectively for relevant literature published from 2005 to 2020. A total of 761 articles were preliminarily searched, and 63 articles that were related to the research purpose were selected and analyzed. RESULTS AND CONCLUSION: MiR-214 can promote osteoclast differentiation by targeting phosphatase-tensin homolog and tumor necrosis factor receptor associated factor 3, and inhibit osteoblast differentiation by targeting transforming growth factor β activated kinase 1 binding protein 2, cadherin protein β1, Osterix, activating transcription factor 4, α1 type IV collagen, baculovirus IAP repeat containing 7, fibroblast growth factor receptor 1, TAFA chemokine-like family member 5, and bone morphogenetic protein 2. Many studies have proved that silencing or overexpression of miR-214 can regulate bone metabolism. It is also found that miR-214 in serum or extracellular vesicles may be a marker for the diagnosis and prognosis of some diseases. It is the focus of its application research to combine miR-214 antagonists with bioscaffold materials to form a stable, efficient and safe sustained release system. Therefore, miR-214 may have great potential in the treatment of bone metabolic diseases in the future.