Biological mechanism of platelet-rich plasma for tendinopathy repair: A visual study based on scientific knowledge map / 中国组织工程研究

ABSTRACT

BACKGROUND: Regeneration and repair using platelet-rich plasma provide a new insight for treating tendinopathy, which exhibits good outcomes in the treatment of refractory tendon and ligament degenerative diseases. OBJECTIVE: To explore the current research hotspot in the treatment of tendinopathy with platelet-rich plasma worldwide through drawing the scientific knowledge map of the treatment to tendinopathy by using the information visualization tool. METHODS: Using citation analysis method, we searched Web of Science core database for the studies on platelet-rich plasma and tendinopathy since 2008. The scientometric and visual analyses of literature were carried out by using Cite Space V scientific knowledge map tool. RESULTS AND CONCLUSION: (1) A total of 515 papers on repair of tendinitis with platelet-rich plasma were recruited. Eight papers on key nodes were obtained, and 27 keywords were found at high frequency. (2) In recent decade, high-yield authors have formed a research group based on the state and research institutions. The inter group cooperation is close, but there is a lack of cross-group scientific research cooperation. (3) Platelet-rich plasma has been widely used in the clinical treatment of tendinopathy, but there are some shortcomings in the design of clinical practice and experimental research, leading to controversy about the therapeutic effect of platelet-rich plasma. In order to evaluate the efficacy of platelet-rich plasma in tendinopathy, basic experimental studies should be carried out on the premise of controlling the experimental conditions and overcoming the shortcomings in experimental design. (4) The research of platelet-rich plasma on tendinopathy in foreign countries has gradually developed from the initial clinical study of platelet-rich plasma on the treatment of tendinopathy to the in vitro experiment with time, which has become a hotspot. In the selection of experimental indicators, the functional study of cytokines contained in platelet-rich plasma has shifted to focus on gene expression in cell biology. It is still unclear which cell transduction pathways platelet-rich plasma can affect tendon healing. From the trend of research, future research in this field will focus on microbiological mechanism of platelet-rich plasma in tendinopathy treatment.