Tissue repair using mesenchymal stem cells via mitochondrial transfer / 中国组织工程研究

ABSTRACT

BACKGROUND: Mesenchymal stem cells have been used in the treatment of various diseases due to their advantages, and mitochondrial transfer is an important mechanism of mesenchymal stem cell therapy. OBJECTIVE: To review the role of mesenchymal stem cells via mitochondrial transfer in various tissue injuries. METHODS: The key words were “stem cells, mitochondrial transfer, cell communication, rescue and repair, tissueinjury” in English and Chinese, respectively. PubMed, CNKI and WanFang databases were retrieved for the articles published from 2008 to 2019. The articles concerning the mitochondrial transfer function and mechanism of mesenchymal stem cells and the treatment of tissue injury were collected. After removal of the repetitive and irrelevant articles, 64 eligible articles were further analyzed. RESULTS AND CONCLUSION: Mesenchymal stem cells have been used in stroke, myocardial infarction, and acute renal failure. Mitochondrial transfer has been widely recognized as a new mechanism of stem cell therapy and has been considered as a potential therapy for tissue injuries. Mitochondrial transfer has been found to be mediated by different modes, including tunnel tube formation, gap junctions, microvesicles, cell fusion and transfer of isolated mitochondria. However, specific mechanisms of mitochondrial transfer in tissue injury have not been fully elucidated and its specific role in tissue repair also needs further investigation.