Hypoxia-mediated mirnas affect glucose metabolism: New recognition of preventing and controlling glucose metabolism / 中国组织工程研究

ABSTRACT

BACKGROUND: MiRNAs have been shown to be closely related to obesity and diabetes, which can be potential biomarkers for the diagnosis and prognosis of diabetes. OBJECTIVE: To review the roles of miRNAs in promoting insulin sensitivity, controlling insulin synthesis and regulating insulin resistance in hypoxic exercise, and to explore the mechanism of hypoxic exercise-mediated miRNAs in regulating glucose metabolism. METHODS: Relevant studies on hypoxic exercise glucose metabolism and miRNAs in PubMed, CNKI, WanFang databases were searched. The keywords were “miRNAs, low oxygen movement, hypoxic exercise, hypoxia-mediated, sugar metabolism, glucose metabolism” in English and Chinese, respectively. Relevant literatures published from 2007 to 2019 were searched and screened according to inclusion and exclusion criteria. RESULTS AND CONCLUSION: MiRNAs have the potential to regulate the expression of major protein cascades in the insulin signaling pathway by regulating the expression of target genes and thereby affecting the homeostasis of glucose metabolism. miRNAs can also be used as single molecules or in combination therapy. There is an urgent need to integrate miRNAs into insulin signaling pathways and develop new miRNAs-related diagnostic and therapeutic approaches in hopes of addressing type 2 diabetes in the future. Studying the mechanism of the effects of miRNAs on glucose metabolism in hypoxic exercise can not only provide a theoretical basis for scientific hypoglycemic and body mass control, but also can be used as an intervention for the prevention and control of diseases related to glucose metabolism disorders. Diseases caused by abnormal glucose metabolism provide new therapeutic approaches.