Survival factors and prognosis of patients with colon cancer in Chongqing / 肿瘤

ABSTRACT

Objective: To analyze the survival of patients with colon cancer who have special medical insurance in Chongqing, and to provide a reference for prognosis evaluation and prevention of colon cancer. Methods: A retrospective cohort study was conducted, and a total of 1 201 patients with colon cancer were enrolled. They were diagnosed and treated from January 2010 to December 2014 in Chongqing Malignant Tumor Treatment System. Follow-up was done by telephone, out-patient and in-patient review to understand the survival of all patients. The end point is the patient's death, and the end time of follow-up is December 31, 2018. The survival rate was calculated by Kaplan-Meier method. The log-rank test was used for the single factor analysis. The COX proportional hazards regression model was used for the multivariate analysis. Survival curves were plotted using GraphPad Prism 8.0 software. Results: The average diagnostic age of 1 201 patients with colon cancer was (64.98±12.71) years. Among them, there were male patients accounting for 58.20%, married patients for 93.78%, still smoking patients for 22.02%, still alcohol-drinking patients for 22.66%, TNM stage patients for 44.27%, and adenocarcinoma patients for 90.33%. The mean survival time of the patients was 84.82 months [95% confidence interval (CI) 82.34-87.30], and the 1-, 3and 5-year observed survival rates were 92.08%, 77.92% and 67.18%, respectively. Multivariate analysis showed that age, TNM staging, surgical treatment and histological differentiation were independent risk factors affecting survival and prognosis of colon cancer patients. Conclusion: The prognosis of patients with colon cancer is relatively good. There are many risk factors affecting the prognosis of patients with colon cancer. Surgical treatment and High degree of differentiation are the protective factors affecting the prognosis of patients.