Advance in preoperative chemotherapy for locally advanced colon cancer / 肿瘤

ABSTRACT

The patients with locally advanced colon cancer have high recurrence rate and poor prognosis after operation, so their quality of life needs to be improved. The present studies show that the early systemic treatment is able to eradicate tumor micrometastasis effectively and reduce the risks of tumor recurrence and metastasis. Preoperative chemotherapy as a kind of systemic treatment is effective for gastric cancer, breast cancer and esophageal cancer, but its curative effect on locally advanced colon cancer is not clear. To explore the feasibility and effectiveness of preoperative chemotherapy for the locally advanced colon cancer and to discuss the treatment strategy of locally advanced colon cancer, this review focuses on the theoretical basis and the clinical efficacy of preoperative chemotherapy for the patients with locally advanced colon cancer, and CT as a mean of screening the patients with preoperative chemotherapy standards and evaluating the curative effect of preoperative chemotherapy, as well as the future research directions of preoperative chemotherapy for colon cancer.