Advances in association of overweight and obesity with cancer development and prognosis / 肿瘤

ABSTRACT

The global prevalence of overweight and obesity has increased dramatically over the past decades. It has been verified that overweight and obesity have been associated with heart disease and type 2 diabetes, as well as the development and prognosis of cancer (such as breast cancer, renal cancer, and endometrium cancer). Adipose tissues surrounding tumor contributes to tumor growth and prognosis through their interactions with malignant cells, secretion of associated molecules (e.g. adipocytokines, proinflammatory cytokines, proangiogenic factors and extracellular matrix constituents) and acting as an energy reservoir for cancer cells. This paper reviews the advances in mechanism of excess body weight and obesity contributing to cancer development and its impact on cancer growth and prognosis.