Elevated Serum Levels of Neopterin in Patients with Behçet's Disease
Annals of Dermatology
;
: 74-78, 1993.
Artículo
en Inglés
| WPRIM
| ID: wpr-84849
ABSTRACT
BACKGROUND:
Neopterin is released from monocytes/macrophages specifically by stimulation with interferon-γ. Therefore the increase refers to the activation of T lymphocytes.OBJECTIVE:
Our objective was to examine the potential role of neopterin in the cell mediated immune response to Behçet's disease.METHODS:
We studied 67 patients of Behçet's disease classified by Shimizu and a control group of 30 normal healthy people. Serum neopterin was detected by radioimmunoassay technique.RESULTS:
The serum neopterin concentration of the group with Behçet's disease was significantly elevated, compared with the control group (6.36 nmol/ml vs 3.63 nmol/ml). The increase of neopterin concentration was well correlated to the clinical severity of the diseases in increasing order.CONCLUSION:
Our data suggest that the T lymphocyte derived IFN-γ which stimulates the production of neopterin has some role in the pathogenesis and clinical severity of Behçet's disease.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Radioinmunoensayo
/
Linfocitos
/
Linfocitos T
/
Interferón gamma
/
Neopterin
Límite:
Humanos
Idioma:
Inglés
Revista:
Annals of Dermatology
Año:
1993
Tipo del documento:
Artículo
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