Synovial sarcoma with extensive ossification and calcification: A report of two cases and literature review / 肿瘤

ABSTRACT

Objective: To explore the clinicopathological features and differential diagnosis of 2 patients with synovial sarcoma with extensive ossification and calcification in order to improve the understanding of the tumor. Methods: The clinical and pathological information of 2 patients with synovial sarcoma with extensive ossification and calcification was reviewed. The EnVision two-step immunohistochemical staining technique was used to detect the expressions of cytokeratin (CK), epithelial membrane antigen (EMA), Bcl-2, CD99 and TLE1. The fluorescence in situ hybridization was used to detect the SS18-SSX fusion gene. Results: Both patients were diagnosed of biphasic synovial sarcoma. The immunohistochemical results showed that CK and EMA expressions were foci-like positive, the Bcl-2, CD99 and TLE1 expressions were positive, and the SS1 8-SSX gene translocation fusion was detected. Conclusion: Synovial sarcoma with extensive ossification and calcification is rare and easily to be confused with osteogenic tumors including osteosarcoma. It should be combined with immunohistochemistry and molecular detection to assist diagnosis.