Correlation of breast cancer and abnormal high-density lipoproteincholesterol level: A Meta-Analysis / 肿瘤

ABSTRACT

Objective: Meta-Analysis was used to assess the association between serum high-density lipoprotein-cholesterol (HDL-C) level and the development of breast cancer. Methods: Studies on the relationship of high-density lipoprotein-cholesterol and the development of breast cancer were retrieved from PubMed, Ovid, EBSCO, Cochrane Library, China National Knowledge Internet, VIP Periodical Resource Integration Service Platform, Wanfang Database and China Biomedical Literature Database from inception to January 9, 2017. Data were extracted from studies which met the inclusion criteria. Standardized mean difference (SMD) was used as an indicator of effect. Literature quality evaluation was carried out according to Newcastle-Ottawa Scale. Stata 12.0 software was used for Meta-Analysis. Results: A total of 12 studies on the association of serum HDL-C level with breast cancer were included in this Meta-Analysis, including 8 204 patients with breast cancer and 230 835 controls. Meta-Analysis showed that the serum HDL-C level was associated with breast cancer [SMD =0.35 (95% confidence interval 0.58 to 0.12), P <0.001]. Subgroup analysis revealed that serum HDL-C level of premenopausal breast cancer patients was lower than that of the controls [SMD =0.15 (95% confidence interval0.29 to 0.01), P = 0.040], but the postmenopausal serum HDL-C level had no obvious relationship with breast cancer [SMD = 0.44 (95% confidence interval0.98 to 0.11), P = 0.110]. In different study regions, the relationship between serum HDL-C level and the development of breast cancer was not clear. Conclusion: HDL-C is related to premenopausal breast cancer, and low serum HDL-C level may increase the risk of premenopausal breast cancer. The relationship between postmenopausal breast cancer and HDL-C is not clear. Given the limitations of the included studies, a larger prospective cohort study is needed to validate the above findings.