Advances in immunotherapy in gastrointestinal cancer / 肿瘤

ABSTRACT

As a new type of antitumor therapy, the use of immune checkpoint inhibitors is a landmark innovation in the treatment of malignant tumors. Previous studies suggest that the immune checkpoint inhibition might be also effective in patients with gastrointestinal cancer. In order to improve the efficacy of immunotherapy, several different strategies are currently under evaluation. In this review, the related discussions in European Organization for Research and Treatment of Cancer (EORTC) Gastrointestinal Tract Cancer Translational Research Meeting in 2014 and American Society of Clinical Oncology (ASCO) annual meeting in the resent two years are summarized. Moreover, the paper reviews the latest clinical research progress about the immunotherapy of gastrointestinal cancers from five aspects: The infiltration of immune cells and new molecular targets, immune checkpoint inhibitors, genetic marker for immunotherapy, combination of checkpoint inhibitors and oncolytic virus, and individualized immunotherapy.