Molecular biology for myelodysplastic syndrome: An update / 肿瘤

ABSTRACT

The pathogenesis of myelodysplastic syndrome (MDS) has not been fully clarified, it may be closely associated with the great heterogeneity in biology that characterizes this group of diseases. Recent studies have revealed that some changes in molecular biology, including abnormal expression of disease gene, abnormal epigenetics, and abnormalities of hematopoietic stem cells, were closely correlated with the pathogenesis of MDS. This article reviews the newly discovered changes of molecular and biological characteristics associated with the development of MDS. Copyright © 2012 by TUMOR.