Relationship between polymorphism of ErbB4 gene in mirco-RNA binding site and the risk for breast cancer / 肿瘤

ABSTRACT

Objective: To investigate the relationship between single nucleotide polymorphism (SNP) of ErbB4 gene in mirco-RNA binding site and the susceptibility of breast cancer. Methods: Genotypes of ErbB4 gene in mirco-RNA binding site at rs1595066 and rs16845990 were measured using the TaqMan SNP method in 1 509 patients with breast cancer and 1 517 healthy controls. Results: Three kinds of genotype of ErbB4 gene in mirco-RNA binding site at rs1595066 were significantly different between breast cancer patients and the healthy controls (P=0.045), while there was no difference at rs16845990 site (P=0.302). The carriers of AG and AA genotypes at rs1595065 site had lower risk of breast cancer than GG genotype [(odds ratio, OR ) = 0.81, 95% (confidence interval, CI ) = 0.69-0.95; OR = 0.75, 95% CI = 0.58-0.96]. Stratified analysis showed that this protective effect was significant in the subjects aged over 55 years, without a history of benign breast disease and without a family history of cancer. Conclusion: The polymorphism of rs1595066 G>A in micro-RNA binding site of ErbB4 gene may be associated with the reduction risk of breast cancer. Copyright© 2011 by the Editorial Board of Tumor.