Expressions of PCNA and EMMPRIN in esophageal squamous cell carcinoma and their clinical significance / 肿瘤

ABSTRACT

Objective: To investigate the expressions of proliferating cell nuclear antigen (PCNA) and extracellular matrix metalloproteinase inducer (EMMPRIN) in esophageal squamous cell carcinoma tissues and their clinical significance. Methods: Immunohistochemistry method was used to detect the expressions of PCNA and EMMPRIN in esophageal squamous cell carcinoma tissues and the normal esophageal epithelial tissues. The correlations of the clinicopathological variables with the expressions of PCNA and EMMPRIN were evaluated. Results: The expression rates of PCNA proteins in esophageal squamous cell carcinoma tissues and the normal esophageal epithelial tissues were 61.25% and 57.5%, respectively, which were both significantly higher than those of EMMPRIN proteins in the corresponding tissues (23.75% and 25.0%, respectively) (P=0.000). The expressions of PCNA and EMMPRIN were significantly associated with the infiltration degree of tumor, lymphatic metastasis, TNM stage and the degree of cell differentiation ( P<0.05). Higher expression levels of PCNA and EMMPRIN indicated poorer prognosis. Conclusion: The expressions of PCNA and EMMPRIN proteins are closely associated with the clinicopathological characteristics of esophageal squamous cell carcinoma. PCNA and EMMPRIN may play an important role in the pathogenesis, progression and lymphatic metastasis in esophageal squamous cell carcinoma.